DILIN Publications

Year DILIN Publications
2020 DILIN0069 Li YJ, Phillips E, Dellinger A, Nicoletti P, Schutte R, Li, D, Ostrov DA, Fontana RJ, Watkins PB, Stolz A, Daly AK, Aithal GP, Barnhart H, Chalasani N. HLA‐B*14:01 and HLA‐B*35:01 are associated with trimethoprim‐sulfamethoxazole induced liver injury. Hepatology. 2020 Accepted Author Manuscript. doi:10.1002/hep.31258. PMID:32270503 PMCID:


2020 DILIN0092 Ghabril M, Gu J, Yoder L, Corbito L, Dakhoul L, Ringel A, Beyer CD, Vuppalanchi R, Barnhart H, Hayashi PH, Chalasani N. Significant Medical Comorbidities Are Associated With Lower Causality Scores in Patients Presenting With Suspected Drug-Induced Liver Injury. Clin Transl Gastroenterol. 2020 Apr;11(4):e00141. doi: 10.14309/ctg.0000000000000141. PMID: 32251016 PMCID:


2020 DILIN0088 Bjornsson HK, Bjornsson ES, Avula B, Khan IA, Jonasson JG, Ghabril M, Hayashi PH, Navarro V. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020 Apr;40(4):825-829. doi: 10.1111/liv.14393. Epub 2020 Feb 11. PMID:31991029 PMCID:


2019 DILIN0075 Kamal N, Koh C, Samala N, Fontana R, Stolz A, Durazo F, Hayashi PH, Phillips E, Wang T, Hoofnagle JH. Asparaginase-induced Hepatotoxicity: Rapid Development of Cholestasis and Hepatic Steatosis. Hepatol Int. 2019 Sep;13(5):641-648. doi: 10.1007/s12072-019-09971-2. Epub 2019 Aug 7. PMID: 31392570 PMCID: PMC7226930


2019 DILIN0063 Ghabril M, Gu J, Yoder L, Corbito L, Ringel A, Beyer CD, Vuppalanchi R, Barnhart H, Hayashi PH, Chalasani N. Development and Validation of Model Consisting of Comorbidity Burden to Calculate Risk of Death Within 6 months for Patients With Suspected Drug-Induced Liver Injury. Gastroenterology. 2019 Jul 11. pii: S0016-5085(19)41085-8. doi: 10.1053/j.gastro.2019.07.006. [Epub ahead of print]. PMID: 31302142


2019 DILIN0094 Bonkovsky HL, Severson T, Nicoletti P, Barnhart H, Serrano J, Chalasani N, Fontana RJ, Watkins PB, Navarro V, Stolz A, Daly A, Aithal GP, Odin J. Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury. Hepatol Commun. 2019 Jun 6;3(8):1032-1035. doi: 10.1002/hep4.1382. PMID: 31388624 PMCID: PMC6671782


2019 DILIN0073 Dipaola F, Molleston JP, Gu J, Cirulli ET, Chalasani N, Barnhart H, Kleiner DE, Hoofnagle JH, Fontana RJ, on behalf of the US Drug Induced Livery Injury Network. Antimicrobials and anti-epileptics are the leading causes of Idiosyncratic Drug Induced Liver Injury in Children. Journal of Pediatric Gastroenterology & Nutrition. 2019 Aug;69(2):152-159. doi: 10.1097/MPG.0000000000002383. PMID: 31169665 PMCID: PMC6658343
2019 DILIN0070 Stolz A, Navarro V, Hayashi PH, Fontana RJ, Barnhart HX, Gu J, Chalasani NP, Vega MM, Bonkovsky HL, Seeff LB, Serrano J, Avula B, Khan IA, Cirulli ET, Kleiner DE, Hoofnagle JH; DILIN Investigators. Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors. Aliment Pharmacol Ther. 2019 May;49(9):1195-1204. doi: 10.1111/apt.15211. Epub 2019 Apr 1. PMID: 30934130 PMCID: PMC6682544


2019 DILIN0066 Navarro V, Avula B, Khan I, Verma M, Seeff L, Serrano J, Fontana R, Ahmad J, Stolz A, for the Drug Induced Liver Injury Network Investigators. The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States are Frequently Mislabeled. Hepatol Commun. 2019 Apr 3;3(6):792-794. doi: 10.1002/hep4.1346. PMID: 31168513 PMCID: PMC6545864


2019 DILIN0064 Ahmad, J., Reddy, KR, Tillmann, HL, Hayashi PH, Chalasani N, Fontana RJ, Navarro VJ, Stolz A, Barnhart H, Cloherty GA, Hoofnagle JH. Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury. Dig Dis Sci. 2019 Sep;64(9):2645-2652. doi: 10.1007/s10620-019-05591-w. PMID: 30927209 PMCID: PMC6706305


2019 DILIN0062 Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, Fontana RJ, Hallberg P, Li YJ, Lucena MI, Long N, Molokhia M, Nelson MR, Odin JA, Pirmohamed M, Rafnar T, Serrano J, Stefansson K, Stolz A, Daly AK, Aithal GP, Watkins PB; on behalf of

Drug-Induced Liver Injury Network (DILIN) investigators and International DILI consortium (iDILIC). A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury. Gastroenterology. 2019 May;156(6):1707-1716.e2. doi: 10.1053/j.gastro.2019.01.034. PMID: 30664875 PMCID: PMC6511989


2018 DILIN0065 Bonkovsky H, Barnhart H, Foureau D, Steuerwald N, Lee W, Gu J, Fontana R, Hayashi P, Chalasani N, Navarro V, Odin J, Stolz A, Watkins P, Serrano J. Cytokine Profiles in Acute Liver Injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. PLoS One. 2018 Oct 25;13(10):e0206389. doi: 10.1371/journal.pone.0206389. eCollection 2018. PubMed PMID: 30359443. PubMed PMCID: PMC6201986.


2018 DILIN0061 Ahmad J, Rossi S, Rodgers SK, Ghabril M, Fontana RJ, Stolz A, Hayashi PH, Barnhart H, Kleiner DE, Bjornsson ES. Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury. Clin Gastroenterol Hepatol. 2019 Mar;17(4):789-790. doi: 10.1016/j.cgh.2018.06.035. Epub 2018 Jun 30. PubMed PMID: 29966706. PubMed PMCID: PMC6311440.


2018 DILIN0060 Fontana RJ, Cirulli ET, Gu J, Kleiner D, Ostrov D, Phillips E, Schutte R, Barnhart H, Chalasani N, Watkins PB, Hoofnagle JH. The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine. J Hepatol. 2018 Dec;69(6):1317-1325. doi: 10.1016/j.jhep.2018.08.004. Epub 2018 Aug 21. PMID: 30138689 PMCID: PMC6472700



2018 DILIN0059 Kowalec K, Wright GEB, Drögemöller B, Aminkeng F, Bhavsar AP, Kingwell E, Yoshida EM, Traboulsee A, Marrie RN, Kremenchutzky M, Campbell TL, Duquette P, Chalasani N, Wadelius M, Hallberg P, Xia Z, De Jager PL, Denny JC, Davis MF, Ross CJD, Tremlett H, and Carleton BC. Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis; 2018 Aug;50(8):1081-1085. doi: 10.1038/s41588-018-0168-y. Epub 2018 Jul 16. PMID: 30013178 PMCID: PMC6513312


2018 DILIN0058 Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P,   Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM, Andrade RJ, van Bömmel F, Poynard T, and Watkins PB. Emerging liver safety biomarkers: an evaluation in healthy volunteers and patients with drug-induced liver injury. Hepatology. 2019 Feb;69(2):760-773. doi: 10.1002/hep.29802. Epub 2018 Jun 27. PubMed PMID: 29357190; PubMed Central PMCID: PMC6054900.


2017 DILIN0057 Ahmad J, Odin JA, Hayashi PH, Chalasani N, Fontana RJ, Barnhart H, Cirulli ET, Kleiner DE, Hoofnagle JH. Identification and Characterization of Fenofibrate-Induced Liver Injury. Dig Dis Sci. 2017; 62: 3596-3604. https://doi.org/10.1007/s10620-017-4812-7. PubMed PMID: 29119413; PubMed PMCID: PMC5694705


2018 DILIN0056 Dakhoul L, Ghabril M, Gu J, Navarro V, Chalasani N, Serrano J, for the United States Drug Induced Liver Injury Network.  Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers. Clinical Gastroenterology and Hepatology, 2018; 16:722-729. PubMed PMID: 29306044. PubMed Central PMCID: PMC5911195.


2017 DILIN0055 Vega M, Verma M, Beswick D, Bey S, Hossack J, Merriman N, Shah A, Navarro V, Drug Induced Liver Injury Network (DILIN). The Incidence of Drug- and Herbal and Dietary Supplement-Induced Liver Injury: Preliminary Findings from Gastroenterologist-Based Surveillance in the Population of the State of Delaware. Drug Saf (2017) 40: 783-787. doi: 10.1007/s40264-017-0547-9. [Epub ahead of print]. PubMed PMID: 28555362. PubMed Central PMCID: PMC5699929


2017 DILIN0054 Hayashi PH, Rockey DC, Fontana RJ, Tillmann HL, Kaplowitz N, Barnhart HX, Gu J, Chalasani NP, Reddy KR, Sherker AH, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN) Investigators. Death and liver transplantation within 2 years of onset of drug-induced liver injury. Hepatology. 2017 Oct;66(4):1275-1285. PubMed PMID: 28543844. PubMed Central PMCID: PMC5605419


2017 DILIN0053 Chalasani N, Reddy KRK, Fontana RJ, Barnhart H, Gu J, Hayashi PH, Ahmad J, Stolz A, Navarro V, Hoofnagle JH. Idiosyncratic Drug Induced Liver Injury in African-Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians. Am J Gastroenterol. 2017 Sep;112(9):1382-1388. doi: 10.1038/ajg.2017.215. Epub 2017 Aug 1. PubMed PMID: 28762375. Central PMCID: PMC5667647


2017 DILIN0052 Urban TJ, Nicoletti P, Chalasani N, Serrano J, Stolz A, Daly A, Aithal G, Dillon J, Navarro V, Odin J, Barnhart H, Ostrov D, Long N, Cirulli ET, Watkins PB, Fontana RJ, on behalf of the Drug-Induced Liver Injury Network (DILIN), the Pharmacogenetics of Drug-Induced Liver Injury group (DILIGEN) and the International Serious Adverse Events Consortium (iSAEC). Minocycline Hepatotoxicity: Clinical characterization and identification of HLA-B* 35:02 as a risk factor. J Hepatol. 2017 Jul;67(1):137-144. doi: 10.1016/j.jhep.2017.03.010. [Epub ahead of print]. PubMed PMID: 28323125. PubMed Central PMCID: PMC5634615


2017 DILIN0051 Suzuki A, Barnhart H, Gu J, Bonkovsky HL, Tillmann HL, Fontana RJ, Kleiner DE, for Drug-induced Liver Injury Network (DILIN). Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury. Liver International. 2017; 37(11):1723-1730. doi: 10.1111/liv.13380. [Epub ahead of print] PubMed PMID: 28161910. Central PMCID: PMC5545077


2017 DILIN0050 Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, and Hoofnagle JH. Liver Injury From Herbal and Dietary Supplements. Hepatology. 2017 Jan;65(1):363-373. doi: 10.1002/hep.28813. Epub 2016 Nov 17. PubMed PMID: 217981596; PubMed Central PMCID:PMC5502701


2017 DILIN0049 Nicoletti P, Aithal GP, Bjornsson ES, Andrade RJ, Sawle A, Arrese M, Barnhart HX, Bondon-Guitton E, Hayashi PH, Bessone F, Carvajal A, Cascorbi I, Cirulli ET, Chalasani N, Conforti A, Coulthard SA, Daly MJ, Day CP, Dillon JF, Fontana RJ, Grove JI, Hallberg P, Hernández N, Ibáñez L, Kullak-Ublick GA, Laitinen T, Larrey D, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Powell EE, Qin S, Serrano J, Stephens C, Stolz A, Wadelius M, Watkins PB, Floratos A, Shen Y, Nelson MR, Urban TJ, Daly AK; International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium. Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study. Gastroenterology. 2017 Apr;152(5):1078-1089. doi: 10.1053/j.gastro.2016.12.016. [Epub ahead of print] PubMed PMID: 28043905. Central PMCID: PMC5367948


2017 DILIN0048 Bonkovsky HL, Kleiner DE, Gu J, Odin JA, Russo MW, Navarro VM, Fontana RJ, Ghabril MS, Barnhart H, Hoofnagle JH, for the US Drug-Induced Liver Injury Network Investigators. Clinical presentations and outcomes of bile duct loss caused by drugs and herbals and dietary supplements. Hepatology 2017 Apr;65(4):1267-1277. Doi: 10.1002/hep.28967. [Epub ahead of print]. PubMed PMID: 217981596; PubMed Central PMCID: PMC5360519.


2017 DILIN0047 Russo MW, Steuerwald N, Norton HJ, Anderson WE, Foureau D, Chalasani N, Fontana RJ, Watkins P, Serrano J, Bonkovsky HL. Profiles of miRNAs in Serum in Severe Acute Drug Induced Liver Injury and their Prognostic Significance. Liver Int. 2017 May;37(5):757-764. doi: 10.1111/liv.13312. [Epub ahead of print]. PubMed PMID: 27860186; PubMed Central PMCID: PMC5502673


2017 DILIN0046 Whritenour J, Ko M, Zong Q, Wang J, Tartaro K, Schneider P, Olson E, VanVolkenburg M, Gu J, Serrano J, Hayashi P, Fontana R, Chalasani N, Bonkovsky HL. Development of a Modified Lymphocyte Transformation Test for Diagnosing Drug Induced Liver Injury Associated with an Adaptive Immune Response. Journal of Immunotoxicology, 2017; 14(1): 31-28. DOI: 10.1080/1547691X.2016.1254305. PubMed PMID: 28121193; PubMed Central PMCID: PMC5505862
2017 DILIN0045 de Boer YS, Kosinski AS, Urban TJ, Zhao Z, Long N, Chalasani N, Kleiner DE, and Hoofnagle JH for the Drug-Induced Liver Injury Network. Features of Autoimmune Hepatitis in Patients with Drug-induced Liver Injury.  Clin Gastroenterol Hepatol. 2017 Jan;15(1):103-112. doi: 10.1016/j.cgh.2016.05.043. [Epub ahead of print] PubMed PMID: 27311619; PubMed Central PMCID: PMC5370577.


2016 DILIN0044 Zheng EX, Rossi S, Fontana RJ, Vuppalanchi R, Hoofnagle JH, Khan I, and Navarro VJ for the Drug Induced Liver Injury Network (DILIN). Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK Weight Loss Products: Results from the DILIN Prospective Study. Drug Saf. 2016 Aug;39(8):749-54. doi: 10.1007/s40264-016-0428-7. PubMed PMID: 27189593; PubMed Central PMCID: PMC4961850.


2016 DILIN0043 Heidemann LA, Navarro VJ, Ahmad, J, Hayashi PH, Stolz A, Kleiner DE, Fontana RJ on behalf of the DILIN Investigators. Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series.    Dig Dis Sci. 2016 Sep;61(9):2741-8. doi: 10.1007/s10620-016-4181-7. Epub 2016 May 3. PubMed PMID: 27142670; PubMed Central PMCID: PMC4982804.


2017 DILIN0042 Björnsson ES, Gu J, Kleiner DE, Chalasani N, Hayashi PH, Hoofnagle JH for the DILIN Investigators. Azathioprine and 6-Mercaptopurine Induced Liver Injury: Clinical Features and Outcomes. J Clin Gastroenterol. 2017 Jan;51(1):63-69. PubMed PMID: 27648552; PubMed Central PMCID:PMC5505863


2016 DILIN0041 deLemos AS, Ghabril M, Rockey DC, Gu J, Barnhart HX, Fontana RJ, Kleiner DE, and Bonkovsky HL for the DILIN study investigators. Amoxicillin-Clavulanate Induced Liver Injury. Digestive Diseases and Sciences; Digestive Disease and Sciences 2016 Aug;61(8):2406-16. doi:10.​1007/​s10620-016-4121-6. PubMed PMID: 27003146; PubMed Central PMCID:PMC4945382


2016 DILIN0040 Schmeltzer PA, Kosinski AS, Kleiner DE, Hoofnagle JH, Stolz A, Fontana RJ, Russo MW, MD for the Drug-Induced Liver Injury Network (DILIN). Liver Injury from Nonsteroidal Anti-inflammatory Drugs in the United States. Liver Int. 2016 Apr;36(4):603-9. doi: 10.1111/liv.13032. [Epub ahead of print]. PubMed PMID: 26601797; PubMed Central PMCID:PMC5035108


2015 DILIN0039 Fontana RJ, Hayashi PH, Barnhart H, Kleiner DE, Reddy KR, Chalasani N, Lee WM, Stolz A, Phillips 3, Serrano J, Watkins PB and DILIN Investigators. Persistent Liver Biochemistry abnormalities are more common in older patients and those with Cholestatic Drug induced Liver Injury. Am J Gastroenterol 2015; 110:1450–1459; doi: 10.1038/ajg.2015.283. PubMed PMID:26346867; PubMed Central PMCID: PMC4784423.


2015 DILIN0038 Usachov V, Urban TJ, Fontana RJ, Gross A, Lyer S, Omary MB, Strnad P. Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury. BMC Medicine (2015) 13:196 DOI 10.1186/s12916-015-0418-0. PubMed PMID:26286715; PubMed Central PMCID:PMC4545365


2015 DILIN0037 Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J; United States Drug Induced Liver Injury Network. Features and Outcomes of 889 Patients with Drug-induced Liver Injury: The DILIN Prospective Study. Gastroenterology. 2015 Jun;148(7):1340-52. doi: 10.1053/j.gastro.2015.03.006. PubMed PMID: 25754159; PubMed Central PMCID:PMC4446235


2015 DILIN0036 Hayashi PH, Fontana RJ, Chalasani NP, Stolz AA, Talwalker JA, Navarro VJ, Lee WM, Davern TJ, Kleiner DE, Gu J, Hoofnagle JH; U.S. DILIN Investigators. Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clin Gastroenterol Hepatol. 2015 Sep;13(9):1676-82. doi: 10.1016/j.cgh.2015.02.024. PubMed PMID: 25724701; PubMed Central PMCID: PMC4653068


2015 DILIN0035 Alqahtani SA, Kleiner DE, Ghabril M, Gu J, Hoofnagle JH, Rockey DC; Drug-Induced Liver Injury Network Study Investigators. Identification and Characterization of Cefazolin-Induced Liver Injury. Clinical Gastroenterology and Hepatology, 2015 Jul;13(7):1328-1336. doi:10.1016/j.cgh.2014.11.036. PMID: 25528012; PubMed Central PMCID:PMC4472636


2015 DILIN0034 Martinez MA, Vuppalanchi R, Fontana RJ, Stolz A, Kleiner DE, Hayashi PH, Gu J, Hoofnagle JH, Chalasani N. Clinical and histologic features of

azithromycin-induced liver injury. Clin Gastroenterol Hepatol 2015 Feb; 13(2): 369-376. PMID: 25111234; PubMed Central PMCID: PMC4321982.


2015 DILIN0033 Vuppalanchi R, Navarro V, Vega M, Bonkovsky HL, Seeff L, Serrano J; Drug-Induced Liver Injury Network (DILIN). Herbal dietary supplement associated hepatotoxicity: an upcoming workshop and need for research. Gastroenterology. 2015 Mar;148(3):480-2. doi: 10.1053/j.gastro.2015.01.004. Epub 2015 Jan 8. PubMed PMID: 25579757;  PubMed Central PMCID: PMC4653067


2016 DILIN0032 Bohm M, Vuppalanchi R, Chalasani N, and the Drug Induced Liver Injury Network (DILIN). Febuxostat-Induced Acute Liver Injury. Hepatology, 2016 Mar;63(3):1047-9. doi: 10.1002/hep.28403. Epub 2016 Feb 3. PubMed PMID: 26679098; PubMed Central PMCID: PMC4764455


2015 DILIN0031 Foureau DM, Walling TL, Maddukuri V, Anderson W, Kleiner DE, Ahrens WA, Jacobs C, McKillop IH, Watkins P, Fontana RJ, Chalasani N, Talwalkar J, Lee WM, Reddy R, Stolz A, Serrano J and Bonkovsky HL. Comparative analysis of portal hepatic infiltrating leukocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis. Clinical Experimental Immunology, 2015 Apr;180(1):40-51. doi: 10.1111/cei.12558. PubMed PMID:25418487; PubMed Central PMCID:PMC4367092


2015 DILIN0030 Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH. Sensitivity to Hepatotoxicity due to Epigallocatechin Gallate is Affected by Genetic Background in Diversity Outbred Mice. Food and Chemical Toxicology. 2015 Feb;76:19-26. doi: 10.1016/j.fct.2014.11.008. Epub 2014 Nov 28. PubMed PMID: 25446466; PubMed Central PMCID: PMC4324012.


2014 DILIN0029 Navarro VJ, Barnhart H,   Bonkovsky HL, Davern T, Fontana RJ, Grant L, Reddy KR, Seeff LB, Serrano J, Sherker AH, Stolz A, Talwalkar J, Vega M, Vuppalanchi R. Liver Injury From Herbals and Dietary Supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology. 2014; 60: 1399–1408. doi: 10.1002/hep.27317. PubMed PMID: 25043597; PubMed Central PMCID: PMC4293199


2014 DILIN0028 Russo MW, Hoofnagle JH, Gu J, Fontana RJ, Barnhart H, Kleiner DE, Chalasani N, Bonkovsky HL. The spectrum of statin hepatotoxicity: Experience of the drug induced liver injury network. Hepatology. 2014 Aug;60(2):679-86. doi: 10.1002/hep.27157. PubMed PMID: 24700436; PubMed Central PMCID:PMC4110177


2014 DILIN0027 Fontana RJ, Hayashi PH, Gu J, Reddy KR, Barnhart H, Watkins PB, Serrano J, Lee WM, Chalasani N, Stolz A, Davern T, Talwakar JA. Idiosyncratic Drug Induced Liver Injury is associated with Substantial Morbidity and Mortality within 6 months From Onset. Gastroenterology. 2014 Jul;147(1):96-108. pii: S0016-5085(14)00429-6. doi: 10.1053/j.gastro.2014.03.045. PubMed PMID: 24681128; PubMed Central PMCID: PMC4285559


2015 DILIN0026 Hayashi PH, Barnhart HX, Fontana RJ, Chalasani N, Davern TJ, Talwalkar JA, Reddy KR, Stolz AA, Hoofnagle JH, Rockey DC. Reliability of Causality Assessment for Drug, Herbal and Dietary Supplement Hepatoxicity in the Drug-Induced Liver Injury Network (DILIN). Liver Int. 2015 May;35(5):1623-32. doi: 10.1111/liv.12540. PubMed PMID: 24661785; PubMed Central PMCID: PMC4305346


2014 DILIN0025 Vuppalanchi R, Gotur R, Reddy KR, Fontana RJ, Ghabril M, Kosinski AS, Gu J, Serrano J, Chalasani N. Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome. Clinical Gastroenterology and Hepatology 2014 Sep;12(9):1550-5. doi: 10.1016/j.cgh.2013.12.016. PubMed PMID: 24362054; PubMed Central PMCID:PMC4065228


2013 DILIN0024 Steuerwald NM, Foureau DM, Norton HJ, Zhou J, Parsons JC, Chalasani N, Fontana RJ, Watkins PB, Lee WM, Reddy KR, Stolz A, Talwalkar J, Davern T, Saha D, Bell LN, Barnhart H, Gu J, Serrano J, Bonkovsky HL. Profiles of serum cytokines in acute drug-induced liver injury and their prognostic significance. PLoS One. 2013 Dec 27;8(12):e81974. doi: 10.1371/journal.pone.0081974. PubMed PMID: 24386086; PubMed Central PMCID:  PMC3873930.


2014 DILIN0023 Kleiner DE, Chalasani NP, Lee WM, Fontana RJ, Bonkovsky HL, Watkins PB, Hayashi PH, Davern TJ, Navarro V, Reddy R, Talwalkar JA, Stolz A, Gu J, Barnhart H, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN). Hepatic histological findings in suspected drug-induced liver injury: Systematic evaluation and clinical associations. Hepatology. 2014 Feb;59(2):661-70. doi: 10.1002/hep.26709. [Epub ahead of print] PubMed PMID: 24037963; PubMed Central PMCID: PMC3946736.


2013 DILIN0022 Navarro VJ, Bonkovsky HL, Hwang SI, Vega M, Barnhart H, Serrano J. Catechins in dietary supplements and hepatotoxicity. Dig Dis Sci. 2013 Sep;58(9):2682-90. doi: 10.1007/s10620-013-2687-9. Epub 2013 Apr 27. PubMed PMID: 23625293; PubMed Central PMCID: PMC3769469.


2013 DILIN0021 Ghabril M, Bonkovsky HL, Kum C, Davern T, Hayashi PH, Kleiner DE, Serrano J, Rochon J, Fontana RJ, Bonacini M; US Drug-Induced Liver Injury Network. Liver injury from tumor necrosis factor-α antagonists: analysis of thirty-four cases. Clin Gastroenterology & Hepatology. 2013 May; 11(5):558-564.e3. Doi: 10.1016/j.cgh.2012.12.025. Epub 2013 Jan 17. PubMed PMID: 23333219; PubMed Central PMCID: PMC3865702.


2013 DILIN0020 Ghabril M, Fontana R, Rockey D, Jiezhun G, Chalasani N. Drug-induced liver injury caused by intravenously administered medications: the Drug-induced Liver Injury Network experience. J Clin Gastroenterol. 2013 Jul; 47(6):553-8. Doi: 10.1097/MCG.0b013e318276bf00. PubMed PMID: 23388845; PubMed Central PMCID: PMC3681898.


2013 DILIN0019 Fontana RJ, Hayashi P, Bonkovsky HL, Kleiner DE, Kochhar S, Gu J, Ghabril M. Presentation and outcomes with clinically apparent interferon beta hepatotoxicity. Dig Dis Sci. 2013 Jun; 58(6):1766-75. Doi: 10.1007/s10620-012-2553-1. Epub 2013 Feb 2. PubMed PMID: 23377559; PubMed Central PMCID: PMC3674196.


2013 DILIN0018 Grant LM, Kleiner DE, Conjeevaram HS, Vuppalanchi R, Lee WM. Clinical and histological features of idiosyncratic acute liver injury caused by temozolomide. Dig Dis Sci. 2013 May; 58(5):1415-21. doi: 10.1007/s10620-012-2493-9. Epub 2012 Dec 5. Review. PubMed PMID: 23212393. PubMed Central PMCID: PMC3826911


2012 DILIN0017 Urban TJ, Shen Y, Stolz A, Chalasani N, Fontana RJ, Rochon J, Ge D, Shianna KV, Daly AK, Lucena MI, Nelson MR, Molokhia M, Aithal GP, Floratos A, Pe’er I, Serrano J, Bonkovsky H, Davern TJ, Lee WM, Navarro VJ, Talwalkar JA, Goldstein DB, Watkins PB; Drug-Induced Liver Injury Network; DILIGEN; EUDRAGENE; Spanish DILI Registry; International Serious Adverse Events Consortium. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. Pharmacogenet Genomics. 2012 Nov; 22(11):784-95. Doi: 10.1097/FPC.0b013e3283589a76. PubMed PMID: 22968431; PubMed Central PMCID: PMC3636716.


2012 DILIN0016 Urban TJ, Goldstein DB, Watkins PB. Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here? Pharmacogenomics. 2012 May; 13(7):735-8. Doi: 10.2217/pgs.12.45. PubMed PMID: 22594502; PubMed Central PMCID: PMC3641893.


2012 DILIN0015 Chalasani N, Vuppalanchi R, Navarro V, Fontana R, Bonkovsky H, Barnhart H, Kleiner DE, Hoofnagle JH. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med. 2012 Jun 19; 156(12):857-60, W297-300. doi: 10.7326/0003-4819-156-12-201206190-00006. PubMed PMID: 22711078. PubMed Central PMCID: PMC3825458


2012 DILIN0014 Bell LN, Vuppalanchi R, Watkins PB, Bonkovsky HL, Serrano J, Fontana RJ, Wang M, Rochon J, Chalasani N; US Drug-Induced Liver Injury Network (DILIN) Research Group. Serum proteomic profiling in patients with drug-induced liver injury. Aliment Pharmacol Ther. 2012 Mar; 35(5):600-12. PubMed PMID: 22403816; PubMed Central PMCID: PMC3654532.


2011 DILIN0013 Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN). Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology. 2011 Nov; 141(5):1665-72.e1-9. Doi: 10.1053/j.gastro.2011.07.051. Epub 2011 Aug 16. PubMed PMID: 21855518; PubMed Central PMCID: PMC3654540.


2011 DILIN0012 Molleston JP, Fontana RJ, Lopez MJ, Kleiner DE, Gu J, Chalasani N; Drug-Induced Liver Injury Network. Characteristics of idiosyncratic drug-induced liver injury in children: results from the DILIN prospective study. J Pediatr Gastroenterol Nutr. 2011 Aug; 53(2):182-9. Doi: 10.1097/MPG.0b013e31821d6cfd. PubMed PMID: 21788760; PubMed Central PMCID: PMC3634369.


2011 DILIN0011 Lucena MI, Molokhia M, Shen Y, Urban TJ, Aithal GP, Andrade RJ, Day CP, Ruiz-Cabello F, Donaldson PT, Stephens C, Pirmohamed M, Romero-Gomez M, Navarro JM, Fontana RJ, Miller M, Groome M, Bondon-Guitton E, Conforti A, Stricker BH, Carvajal A, Ibanez L, Yue QY, Eichelbaum M, Floratos A, Pe’er I, Daly MJ, Goldstein DB, Dillon JF, Nelson MR, Watkins PB, Daly AK; Spanish DILI Registry; EUDRAGENE; DILIN; DILIGEN; International SAEC. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology. 2011 Jul; 141(1):338-47. doi: 10.1053/j.gastro.2011.04.001. Epub 2011 Apr 12. PubMed PMID: 21570397; PubMed Central PMCID:


2011 DILIN0010 Orman ES, Conjeevaram HS, Vuppalanchi R, Freston JW, Rochon J, Kleiner DE, Hayashi PH; DILIN Research Group. Clinical and histopathologic features of fluoroquinolone-induced liver injury. Clinical Gastroenterology & Hepatology. 2011 Jun; 9(6):517-523.e3. doi: 10.1016/j.cgh.2011.02.019. Epub 2011 Feb 26. PubMed PMID: 21356330; PubMed Central PMCID: PMC3718017.


2010 DILIN0009 Vuppalanchi R, Hayashi PH, Chalasani N, Fontana RJ, Bonkovsky H, Saxena R, Kleiner D, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN). Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network. Aliment Pharmacol Ther. 2010 Nov; 32(9):1174-83. Doi: 10.1111/j.1365-2036.2010.04449.x. Epub 2010 Sep 3. PubMed PMID: 20815829. PubMed Central PMCID: PMC3773985


2010 DILIN0008 Fong TL, Klontz KC, Canas-Coto A, Casper SJ, Durazo FA, Davern TJ 2nd, Hayashi P, Lee WM, Seeff LB. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol. 2010 Jul; 105(7):1561-6. Doi: 10.1038/ajg.2010.5. Epub 2010 Jan 26. PubMed PMID: 20104221. PubMed Central PMCID: PMC3825455


2010 DILIN0007 Rockey DC, Seeff LB, Rochon J, Freston J, Chalasani N, Bonacini M, Fontana RJ, Hayashi PH; US Drug-Induced Liver Injury Network. Causality assessment in drug-induced liver injury using a structured expert opinion process: comparison to the Roussel-Uclaf causality assessment method. Hepatology. 2010 Jun; 51(6):2117-26. Doi: 10.1002/hep.23577. PubMed PMID: 20512999; PubMed Central PMCID: PMC3249230.


2010 DILIN0006 Agarwal VK, McHutchison JG, Hoofnagle JH; Drug-Induced Liver Injury Network. Important elements for the diagnosis of drug-induced liver injury. Clin Gastroenterol Hepatol. 2010 May; 8(5):463-70. Doi: 10.1016/j.cgh.2010.02.008. Epub 2010 Feb 17. Review. PubMed PMID: 20170750.  PMCID: PMC3901223


2010 DILIN0005 Fontana RJ, Seeff LB, Andrade RJ, Björnsson E, Day CP, Serrano J, Hoofnagle JH. Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop. Hepatology. 2010 Aug; 52(2):730-42. Doi: 10.1002/hep.23696. PubMed PMID: 20564754; PubMed Central PMCID: PMC3616501.


2010 DILIN0004 Stewart JD, Horvath R, Baruffini E, Ferrero I, Bulst S, Watkins PB, Fontana RJ, Day CP, Chinnery PF. Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity. Hepatology. 2010 Nov; 52(5):1791-6. Doi: 10.1002/hep.23891. PubMed PMID: 21038416; PubMed Central PMCID:PMC3841971.


2009 DILIN0003 Fontana RJ, Watkins PB, Bonkovsky HL, Chalasani N, Davern T, Serrano J, Rochon J; DILIN Study Group. Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct. Drug Safety. 2009; 32(1):55-68. doi: 10.2165/00002018-200932010-00005. PubMed PMID: 19132805; PubMed Central PMCID: PMC3637941.


2008 DILIN0002 Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J; Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology. 2008 Dec; 135(6):1924-34, 1934.e1-4. Doi: 10.1053/j.gastro.2008.09.011. Epub 2008 Sep 17. PubMed PMID: 18955056; PubMed Central PMCID: PMC3654244.


2008 DILIN0001 Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG; Drug-Induced Liver Injury Network (DILIN). Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury. Hepatology. 2008 Oct; 48(4):1175-83. Doi: 10.1002/hep.22442. PubMed PMID: 18798340; PubMed Central PMCID: PMC3618289.